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Suprofen(TN-762)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Suprofen(TN-762)图片
CAS NO:40828-46-4
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议
1g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)260.31
FormulaC14H12O3S
CAS No.40828-46-4
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 52 mg/mL (199.8 mM)
Water: <1 mg/mL
Ethanol: 52 mg/mL (199.8 mM)
Solubility (In vivo)

Chemical Name: 2-(4-(thiophene-2-carbonyl)phenyl)propanoic acid

InChi Key: MDKGKXOCJGEUJW-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H12O3S/c1-9(14(16)17)10-4-6-11(7-5-10)13(15)12-3-2-8-18-12/h2-9H,1H3,(H,16,17)

SMILES Code: CC(C1=CC=C(C(C2=CC=CS2)=O)C=C1)C(O)=O

Synonyms

R-25061;TN-762; R25061; TN 762; R 25061; TN762; Suprofen; Suprofenum; Profenal

实验参考方法
In Vitro

In vitro activity: Suprofen inactivates the diclofenac-4-hydroxylase activity of baculovirus-expressed P450 2C9 in a time- and concentration-dependent manner, which is consistent with mechanism-based inactivation. Suprofen is a known generator of singlet oxygen whose participation in the reaction is supported by the effects of quenchers and scavengers. Suprofen photosensitizes the production of alkali-labile cleavage sites in DNA much more efficiently than direct strand breaks. Suprofen sensitizes photo-oxidation of cholesterol, producing 7 alpha- and 7 beta-hydroperoxides but not 5 alpha-hydroperoxide of cholesterol. Suprofen-sensitized photo-oxidation of membrane lipids of liposomes increases leakage of trapped glucose, suggesting photosensitized destabilization of the membrane structure. Suprofen incorporation in the phosphatidylcholine (PC) evaporation vesicles (REV) membrane leads to approximately 5% increase in the encapsulation efficiency (34%) in comparison to standard REV (29%).

In VivoSuprofen combined with PGF2 alpha blocks induction of uterine contractions, suggesting the possibility that Suprofen also antagonizes PGF2 alpha receptor binding. Suprofen are effective at preventing BAB disruption after paracentesis in dogs, indicating their potential usefulness for treatment of prostaglandin-mediated ocular disease. Suprofen (3.7 mg/kg, i.v.) induces a marked decrease in the firing evoked in arthritic rats by ankle mobilization.
Animal modelRats
Formulation & Dosage3.7 mg/kg, i.v.
References

Drug Metab Dispos. 2003 Nov;31(11):1369-77; Am J Vet Res. 1996 Jun;57(6):875-8.