MAPK-IN-1 (Compound 2) is aMAPK signaling pathwayinhibitor. MAPK-IN-1 exhibitsAChEinhibitory activity with anIC₅₀of 23.84 μM. MAPK-IN-1 shows anti-neuroinflammatory and neuroprotective activity and can be used for Alzheimer's disease research^[1].

MAPK-IN-1 (Compound 2) inhibits NO, IL-1β, IL-6, and TNF-α release in BV-2 cells withIC₅₀values of 0.49 ± 0.17, 1.34 ± 0.21, 9.17 ± 0.17 and 8.17 ± 0.23 μM, respectively^[1].
MAPK-IN-1 downregulates LPS-induced phosphorylation of JNK, ERK, and p38 in MAPK signaling pathway^[1].
MAPK-IN-1 inhibits expressions of iNOS, COX-2, and TLR4 in LPS-induced BV-2 cells^[1].

310.34

C₁₉H₁₈O₄

2470587-69-8

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