Diprovocim-X (compound 35) is a potentTLR1/TLR2(toll-like receptor 1/2) agonist, withEC₅₀values of 0.14 and 0.75 nM for hTLR1/TLR2 and mTLR1/TLR2, respectively. Diprovocim-X is a potent adjuvantin vivoin mice, and serves to stimulate the adaptive immune response^[1].

Diprovocim-X stimulates release of TNF-α from (human) differentiated THP-1 cells proves dependent on both TLR2 and TLR1, but notably independent of TLR6^[1].

1134.41

Solid

C₆₆H₈₃N₇O₁₀

Room temperature in continental US; may vary elsewhere.