TH1020 is a potent and selectivetoll-like receptor5 (TLR5)/flagellin complexantagonist with anIC₅₀of 0.85 μM. TH1020 inhbits flagellin-inducedTLR5signaling. TH1020 is inactive againstTLR2,TLR3,TLR4,TLR7andTLR8^[1].

IC50: 0.85 μM (toll-like receptor 5 (TLR5)/flagellin complex)^[1]

TH1020 inhibits the downstream signaling transduction mediated by the formation of the TLR5/Flagellin complex. TH1020 is suggested to compete with flagellin and disrupt its association with TLR5. TH1020 almost completely abolishes the TLR5-mediated TNF-α secretion at 0.37 μM^[1].
The IL-17C secretion is almost completely abolished by TH1020 (0.5 μM) in bacterial strain C83901 infected IPEC-J2 cells^[2].
Blocking TLR5 with TH1020 (0.5 μM) dramatically inhibits porcine beta-defensin (pBD)-2, claudin-1 and -2 mRNA expression in C83091 infected IPEC-J2 cells^[2].

453.54

Solid

C₂₃H₁₅N₇S₂

1841460-82-9

Room temperature in continental US; may vary elsewhere.

DMSO : 2 mg/mL(4.41 mM;ultrasonic and warming and adjust pH to 2 with 1M HCl and heat to 80℃)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。