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c-di-AMP diammonium
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
c-di-AMP diammonium图片
包装与价格:
包装价格(元)
500 μg电议
1mg电议
5mg电议
10mg电议

产品名称
Cyclic diadenylate diammonium
Cyclic-di-AMP diammonium
产品介绍
c-di-AMP diammonium 是STING激动剂,其与 STING 结合,从而激活 TBK3-IRF3 信号传导途径,随后引发 I 型 IFN 和 TNF 产生。c-di-AMP diammonium 是一种细菌第二信使,主要在革兰氏阳性细菌中,可调节细胞生长,存活以及毒力。c-di-AMP diammonium 也调节宿主免疫反应。c-di-AMP diammonium 可作为一种有效的粘膜佐剂,刺激体液和细胞反应。
生物活性

c-di-AMP diammonium is aSTINGagonist, which binds to the transmembrane proteinSTINGthereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP diammonium is also abacterialsecond messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP diammonium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses[1][2][3][4].

IC50& Target

STING[3]

体外研究
(In Vitro)

c-di-AMP diammonium signaling is a central factor in many Gram-positive bacteria regulating cell wall synthesis, potassium ion channels, DNA repair, and biofilm formation. c-di-AMP is also essential for cell growth, survival, and virulence of several well-known human pathogenic bacteria includingS. aureus,L. monocytogenes,S. pyogenes, andMycobacterium spp[1].
c-di-AMP diammonium combines with model antigens, such as OVA or β-Gal, acts as a potent mucosal adjuvant stimulating both humoral and cellular responses[4].

分子量

692.47

性状

Solid

Formula

C20H30N12O12P2

中文名称

环二腺苷酸(联胺)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO :< 1 mg/mL (ultrasonic;warming;heat to 60℃)(insoluble or slightly soluble)