C-178 is a potent and selective covalent inhibitor ofSTING. C-178 binds to Cys91 and suppresses theSTINGresponses elicited by distinct bona fide activators in mouse but not human^[1].

STING^[1]

C-178 targets the poorly characterized N-terminal portion of mmSTING that includes the transmembrane domains. Moreover, C-178 interferes with this process by inhibiting the palmitoylation of STING. C-178 does not appreciably affect STING responses in human cells^[1].
C-178 (0-1 μM; 1 hour) alone does not appreciably affect the gene expression profile of BMDMs. In addition, it inhibits the CMA-induced phosphorylation of TBK1^[1].
C-178 (1 μM; 1 hour) decreases cdG, dsDNA, CMA and LPS-inducedIfnb1expression in mouse bone marrow-derived macrophages^[1].
C-178 (1 μM; 0.5-4 hours) inhibits the CMA-induced p-TBK1 and sting protein expression as a time-dependent manner in mouse embryonic fibroblasts^[1].

322.27

Solid

C₁₇H₁₀N₂O₅

329198-87-0

Room temperature in continental US; may vary elsewhere.

DMSO : 41.67 mg/mL(129.30 mM;Need ultrasonic)

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