AUNP-12 (NP-12) is a peptide antagonist of thePD-1signaling pathway, displays equipotent antagonism towardPD-L1and PD-L2 in rescue of lymphocyte proliferation and effector functions. AUNP-12 exhibits immune activation, excellent antitumor activity, and potential for better management of immune-related adverse events (irAEs)^[1].

PD-1 signaling pathway^[1]

AUNP-12 displays equipotent antagonism toward PD-L1 and PD-L2 in rescue of lymphocyte proliferation and effector functions^[1].
AUNP-12 rescues the proliferation in the mouse splenocyte assay system, with average EC₅₀values of 17 nM and 16.6 nM against rmPD-L1 and rmPD-L2 respectively^[1].
AUNP-12 is also able to significantly rescue recombinant human PD-L1 and PD-L2 mediated inhibition of in vitro human PBMC proliferation, with average EC₅₀values of 63.3 nM and 44.1 nM against PD-L1 and PD-L2 respectively^[1].

3261.55

Solid

C₁₄₂H₂₂₆N₄₀O₄₈

1353563-85-5

H-SNTSESFKF(H-SNTSESF)RVTQLAPKAQIKE-NH2

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

H₂O : 10 mg/mL(3.07 mM;Need ultrasonic)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。