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7,8-Dihydroneopterin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
7,8-Dihydroneopterin图片
CAS NO:1218-98-0
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品名称
7,8-二氢-D-新蝶呤
产品介绍
7,8-Dihydroneopterin 是一种炎症标记,通过增强一氧化氮合酶 (iNOS) 的表达来诱导星形胶质细胞和神经元细胞凋亡 (apoptosis)。可用于神经退行性疾病的研究。
生物活性

7,8-Dihydroneopterin, an inflammation marker, induces cellularapoptosisin astrocytes and neurons via enhancement of nitric oxide synthase (iNOS) expression. 7,8-Dihydroneopterin can be used in the research of neurodegenerative diseases[1].

IC50& Target

iNOS

 

Human Endogenous Metabolite

 

体外研究
(In Vitro)

7,8-Dihydroneopterin is a heterocyclic pteridine which produced and secreted by monocytes/macrophages upon stimulation with the cytokine interferon-y (IFN-y)[1].
7,8-Dihydroneopterin (0.1, 0.5, 1, 2.5, 5 mM; 2 days and 5 days) inhibits growth of U373MG astroeytes[1].

Cell Viability Assay[1]

Cell Line:Astrocytic cell line U373MG
Concentration:0.1, 0.5, 1, 2.5, 5 mM
Incubation Time:2 days and 5 days
Result:After 2 days of treatment, a significantly lower cell number was observed for those cells treated with 5 mM and 2.5 mM.
After incubation for 5 days concentrations of 1-5 mM completely abrogated acid phosphatase activity to background level found for complete cell culture medium.
A significant cell growth inhibition was also visible for the cells incubated with 0.5 mM, whereas 0.1 mM did not alter cell growth.
分子量

255.23

性状

Solid

Formula

C9H13N5O4

CAS 号

1218-98-0

中文名称

7,8-二氢-D-新蝶呤

结构分类
  • Others
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
In solvent-80°C6 months
-20°C1 month