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Antagonist G
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Antagonist G图片
CAS NO:115150-59-9
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议

产品介绍
Antagonist G 是有效的后叶加压素 (vasopressin) 的拮抗剂。Antagonist G 也是弱的 GRP 和缓激肽的弱拮抗剂。Antagonist G 可诱导 AG-1 的转录,是癌细胞对化疗增敏。
生物活性

Antagonist G is a potentvasopressinantagonist. Antagonist G is also a weak antagonist of GRP and Bradykinin. Antagonist G inducesAP-1transcription and sensitizes cells to chemotherapy[1][2].

体外研究
(In Vitro)

Antagonist G (0-100 μM) induces apoptosis is redox-sensitive and caspase-dependently in SCLC cells[2].
Antagonist G activates JNK1 in SCLC cells[2].
Antagonist G is not intrinsically a free radical oxygen donor but stimulates free radical generation specifically within SCLC cells (6.2-fold) and increases the activity of the redox-sensitive transcription factor AP-1 by 61%[2].

Cell Viability Assay[2]

Cell Line:SCLC cell lines NCI-H69, NCI-H510 and CHO-K1 cells.
Concentration:0-100 μM.
Incubation Time:24 h.
Result:Inhibited cell growh.
分子量

951.19

性状

Solid

Formula

C49H66N12O6S

CAS 号

115150-59-9

Sequence Shortening

RW-{Me-Phe}-WLM-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light

Powder-80°C2 years
-20°C1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro: 

H2O : 50 mg/mL(52.57 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM1.0513 mL5.2566 mL10.5131 mL
5 mM0.2103 mL1.0513 mL2.1026 mL
10 mM0.1051 mL0.5257 mL1.0513 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture and light)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。