d[Cha4]-AVP is a potent and selectivevasopressin (AVP) V1b receptoragonist with aK_iof 1.2 nM forhuman V1b receptor. d[Cha4]-AVP shows more selective for V1b receptor than human V1a receptor, V2 receptor, and oxytocin receptors^[1][2].

Ki: 1.2 nM (vasopressin V1B receptor), 151 nM (vasopressin V1A receptor), 240 nM (Oxytocin receptor), 750 nM (vasopressin V2 receptor)^[1]

d[Cha4]-AVP binds to hV1b receptors and human oxytocin receptors with pK_ivalues of 9.68 and 7.68, respectively^[2].
d[Cha4]-AVP stimulates [Ca²⁺]_iincrease in hV1b-CHO cells with a pEC₅₀value of 10.05. d[Cha4]-AVP shows pEC₅₀values of 6.53 and 5.92 at hV1a and hV2 receptors, respectively, and behaved as a weak antagonist at hOT receptors (pKB=6.31)^[2].

1094.31

Solid

C₅₀H₇₁N₁₃O₁₁S₂

500170-27-4

{Mpa}-Tyr-Phe-{Cha}-Asn-Cys-Pro-Arg-Gly-NH2 (Disulfide bridge:Mpa1-Cys6)

{Mpa}YF{Cha}NCPRG-NH2 (Disulfide bridge:Mpa1-Cys6)

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

H₂O : 100 mg/mL(91.38 mM;Need ultrasonic)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。