CAS NO: | 220460-92-4 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | WAY-151932 is avasopressin V2-receptoragonist withIC50of 80.3 nM and 778 nM in human-V2binding and V1abinding assay. | ||||||||||||||||
IC50& Target | IC50: 80.3 nM (human-V2 binding), 778 nM (human-V1a binding)[1] | ||||||||||||||||
体外研究 (In Vitro) | WAY-151932 (VNA-932) stimulates cAMP formation in LV2 cells expressing the hV2receptors in a dose-dependent manner with an EC50of 0.74±0.07 nM[2]. | ||||||||||||||||
体内研究 (In Vivo) | Oral administration of WAY-151932 (VNA-932) to water-loaded conscious rats produces a dose-dependent decrease in urine volume (ED50=0.14 mg/kg, 2.5% starch in water vehicle) and a corresponding increase in osmolality without altering the urine electrolyte excretion profile[2]. | ||||||||||||||||
分子量 | 402.88 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C23H19ClN4O | ||||||||||||||||
CAS 号 | 220460-92-4 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 200 mg/mL(496.43 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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