TT-232

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TT-232

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

147159-51-1

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

CAP-232
TLN-232

产品介绍

TT-232 (CAP-232)，一种生长抑素衍生物，是一种多肽类SSTR1/SSTR4激动剂。TT-232 抑制癌细胞增殖并诱导细胞凋亡 (apoptosis)。TT-232 也是一种广谱抗炎镇痛剂。

生物活性

TT-232 (CAP-232), a somatostatin derivative, is a peptideSSTR1/SSTR4agonist. TT-232 inhibitscancercell proliferation and inducesapoptosis. TT-232 is also a broad-spectrum anti-inflammatory and analgesic agent^[1]^[2]^[4].

IC₅₀& Target^[4]

SSTR1

SSTR4

体外研究
(In Vitro)

TT-232 (10 μg/mL, 48 h) induces apoptosis in human colon (HT-29 and SW620), pancreatic (818), leukemia (K-562), melanoma (WM 938/B, M-1 and EP) and lymphoma (HT-58) tumor cell lines^[1].
TT-232 (20-30 μg/mL, 24 h) shows antiproliferative effect on various human tumor cell lines^[2].

Cell Viability Assay^[2]

Cell Line:	MCF7, PC-3, P818, K-562, 4-1ST, ect.
Concentration:	20-30 μg/mL
Incubation Time:	24 h
Result:	Inhibited cell proliferation by 87%, 90%, 98%, 95%, respectively.

体内研究
(In Vivo)

TT-232 (15-750 μg/kg/day, twice a day) inhibits tumor growth in mice transplanted with Colon 26 cell^[2].
TT-232 (0.6 or 15 μg/kg s.c or i.p.) shows antitumor effect on P-388 rodent lymphocytic leukemia tumor mice^[3].
TT-232 (7.5-20 μg/kg, i.v.) inhibits Carrageenin-induced paw oedema in rats^[4].

Animal Model:	Mice transplanted with Colon 26 cell^[2].
Dosage:	15, 150, 750 μg/kg/day
Administration:	Intraperitoneal injection (i.p.)
Result:	Reached 70% tumor inhibition at 750 μg/kg.

Clinical Trial

分子量

947.13

Formula

C₄₅H₅₈N₁₀O₉S₂

CAS 号

147159-51-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.