包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | K20 is a potent and selectiveKRas G12Cinhibitor with anIC50of 1.16 μM. K20 shows anticancer activity in H358 cells (IC50= 0.78 μM). K20 decreases the levels of phosphorylatedErkand leads tocancercellapoptosis. K20 suppresses NCI-H358 tumor growth with aTGIof 41% without causing obvious toxicity[1]. | ||||||||||||||||||||||||
IC50& Target |
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体外研究 (In Vitro) | K20 (24 h) shows selective cytotoxicity (5 to 23-fold) against KRas G12C mutated cells (H358, IC50=0.78 μM) over other KRas mutant (e.g.G12D, G12D, G12S, G12V) cancer cells (IC50s of 6.34, 17.74, 4.78, 5.03, 4.05 μM in HCT116 (G13D), A549 (G12S), Pancl (G12D), Hela (WT), SW620 (G12V), respectively)[1]. Cell Cytotoxicity Assay[1]
Apoptosis Analysis[1]
Western Blot Analysis[1]
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体内研究 (In Vivo) | K20 (35 mg/kg; i.p.; every other day for 14 days) shows high tumor suppressive effects with a tumor growth inhibition (TGI) of 41% at 35 mg/kg[1].
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分子量 | 543.34 | ||||||||||||||||||||||||
Formula | C24H20Cl2F4N4O2 | ||||||||||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |