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Amfenac Sodium Monohydrate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Amfenac Sodium Monohydrate图片
CAS NO:61618-27-7
规格:≥98%
包装与价格:
包装价格(元)
50mg电议
100mg电议
250mg电议
500mg电议
1g电议
2g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)295.27
FormulaC15H12NO3.H2O.Na
CAS No.61618-27-7
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 59 mg/mL (199.8 mM)
Water: 59 mg/mL (199.8 mM)
Ethanol: 4 mg/mL (13.5 mM)
Other infoChemical Name: Benzeneacetic acid, 2-amino-3-benzoyl-, sodium salt, monohydrate

InChi Key: QZNJPJDUBTYMRS-UHFFFAOYSA-M

InChi Code: InChI=1S/C15H13NO3.Na.H2O/c16-14-11(9-13(17)18)7-4-8-12(14)15(19)10-5-2-1-3-6-10;;/h1-8H,9,16H2,(H,17,18);;1H2/q;+1;/p-1

SMILES Code: O=C([O-])CC1=CC=CC(C(C2=CC=CC=C2)=O)=C1N.[H]O[H].[Na+]

SynonymsAHR 5850; AHR5850; AHR5850
实验参考方法
In Vitro

In vitro activity: Amfenac is a potent inhibitor of both COX-1 and COX-2 with IC50 of 0.25 and 0.15 μM.


Cell Assay: Human uveal melanoma cell lines are transfected to constitutively express COX-2 and the proliferative rate of these cells using two different methods, with and without the addition of Amfenac Sodium Hydrate, is measured. Nitric oxide production by macrophages is measured after exposure to melanoma-conditioned medium from both groups of cells as well as with and without Amfenac Sodium Hydrate

In VivoAmfenac possesses both antipyretic and analgesic properties in vivo. Amfenac (4 mg/kg) suppressed acute (Evans blue-carrageenan pleural effusion) and chronic (adjuvant-induced arthritis) inflammation by 33% and 28%, respectively, which is 16.4 and 22.8 times more potent than phenylbutazone. The analgesic activity of Amfenac is 43 times that of acetylsalicylic acid in the Randall-Selitto assay, and 156 and 56.3 times more potent than phenylbutazone in the acetylcholine-induced abdominal constriction in mice and in the bradykinin-induced nociceptive response in dogs, respectively. Amfenac produces less gastric irritation than acetylsalicylic acid when applied topically to the exposed gastric mucosa of cats or when administered orally to rats and dogs. Upon subchronic oral administration to rats, the therapeutic ratio of Amfenac is twice that of phenylbutazone.
Animal modelCats, rats, dogs
Formulation & Dosagetopical
References

Inflammation. 2000 Aug;24(4):357-70; Agents Actions. 1977 Mar;7(1):133-44; J Carcinog. 2007 Nov 27;6:17.