R-(+)-Etomoxir, R-isomer of etomoxir, is a novel and potent inhibitor of CPT1 (carnitine palmitoyltransferase A), which is required for the oexidation of long-chain acyl CoA esters. Etomoxir is an irreversible inhibitor of carnitine palmitoyltransferase-1 (CPT-1) on the outer face of the inner mitochondrial membrane. It inhibits β-oxidation in mitochondria; shown to inhibit cardiolipin biosynthesis from exogenous fatty acid in H9c2 cells. Etomoxir has also been identified as a direct agonist of PPARα. Etomoxir is a compound that binds irreversibly to the catalytic site of CPT-1 inhibiting its activity, but also upregulates fatty acid oxidation enzymes.

纯度：≥98%

CAS：132308-39-5