BMS-986120 is a first-in-class oral and reversibleprotease-activated receptor4 (PAR4) antagonist, withIC₅₀sof 9.5 nM and 2.1 nM in human and monkey blood, respectively. BMS-986120 has potent and selective antiplatelet effects^[1][2].

IC50: 9.5 nM (PAR4, human), 2.1 nM (PAR4, monkey)^[1]

BMS-986120 has high binding affinity to PAR4 expressed on HEK293 cells and inhibition of PAR4-induced calcium mobilization with an IC₅₀of 0.56 nM^[3].

In monkeys, BMS (1 mg/kg) does not inhibit PA induced by PAR1-AP, ADP and collagen, supporting selectivity. BMS (0.2, 0.5, 1 mg/kg) reduces TW by 35±5, 49±4, and 83±4%, respectively. Maximum KBT and MBT increases are only 2.2-fold and 1.8-fold, respectively^[1].

513.59

Solid

C₂₃H₂₃N₅O₅S₂

1478712-37-6

Room temperature in continental US; may vary elsewhere.

DMSO : 3.33 mg/mL(6.48 mM;ultrasonic and warming and heat to 80℃)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。