CAS NO: | 634193-54-7 |
包装: | 1mg (11.92 mM * 200 μL in Methanol) |
市场价: | 9500元 |
生物活性 | L-902688 is a potent, selective and orally activeEP4 receptoragonist with aKiof 0.38 nM and anEC50of 0.6 nM. L-902688 shows >4,000-fold selective forEP4over otherEPand prostanoid receptors[1][2]. | ||||||||
IC50& Target[2] |
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体外研究 (In Vitro) | L-902688 (1 μM; 24 hours; HUVE cells) treatment attenuates TGF-β-induced Twist and α-smooth muscle actin (α-SMA) expression[1]. Western Blot Analysis[1]
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体内研究 (In Vivo) | L-902688 (0.25-1 μg/kg/day; intraperitoneal injection; daily; for 3 weeks; adult male Sprague-Dawley rats) treatment reduces right ventricle fibrosis in the monocrotaline (MCT)-induced PAH rat model[1].
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分子量 | 419.47 | ||||||||
性状 | Liquid | ||||||||
Formula | C21H27F2N5O2 | ||||||||
CAS 号 | 634193-54-7 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Solution, -20°C, 2 years |