CAS NO: | 217813-15-5 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | KW-8232, an orally active anti-osteoporotic agent, and can reduces the biosynthesis ofPGE2[1]. | ||||||||||||||||
IC50& Target | Prostaglandin Receptor[1] | ||||||||||||||||
体外研究 (In Vitro) | KW-8232 is an anti-osteoporotic agent. KW-8232 reduces the biosynthesis of PGE2in mouse osteoblastic cells[1]. | ||||||||||||||||
体内研究 (In Vivo) | KW-8232 (3, 10, 30 mg/kg, p.o.) potently increases the femoral bone mineral density (BMD) of immobilized legs of rats, and affects immobilization-induced abnormal bone turnovrer. KW-8232 markedly decreases urinary calcium excreation in the neurectomized rats only at 30 mg/kg, and highly reduces urinary pyridinoline and deoxypyridionline excretion which are markers of bone resorption in neurectomized rats. KW-8232 inhibits bone loss may be attributed to the lower prostaglandins (PGs)-stimulated bone resorption via regulation of PGE2 production[1].
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分子量 | 705.26 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C37H41ClN4O6S | ||||||||||||||||
CAS 号 | 217813-15-5 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 125 mg/mL(177.24 mM;Need ultrasonic) 配制储备液
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