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PPTN
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PPTN图片
CAS NO:1160271-30-6
包装:1mg

产品介绍
PPTN 是一种有效,高亲和力,竞争性和高选择性的P2Y14受体拮抗剂,KB为 434 pM。PPTN 对 P2Y1,P2Y2,P2Y4,P2Y6,P2Y11,P2Y12 或 P2Y13 受体无激动剂或拮抗剂作用。具有抗炎和免疫活性。
生物活性

PPTN is a potent, high-affinity, competitive and highly selectiveP2Y14 receptorantagonist with aKBvalue of 434 pM. PPTN exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors. Anti-inflammatory and immune activity[1].

IC50& Target

KB: 434 pM (P2Y14 receptor)[1]

体外研究
(In Vitro)

PPTN exhibits strong selectivity for the P2Y14-R over the other seven nucleotide-activated P2Y receptors. 1 μM PPTN exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors[1].
PPTN inhibits UDP-glucose-promoted chemotaxis in differentiated HL-60 human promyelocytic leukemia cells with IC50s of ~1 nM in the presence of 10 μM UDP-glucose and ~4 nM in the presence of 100 μM[1].
PPTN (10 μM) significantly decreases the ratios of p-ERK1/2 to ERK1/2 and p-p38 to p38[2].

分子量

475.50

Formula

C29H24F3NO2

CAS 号

1160271-30-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.