NF546 is a selective non-nucleotideP2Y11agonist with apEC₅₀of 6.27. NF546 stimulates release of interleukin-8 from human monocyte-derived dendritic cells^[1].

pEC50: 6.27 (P2Y11)^[1]

NF546 is relatively selective for P2Y11 over P2Y1, P2Y2, P2Y4, P2Y6, P2Y12, P2X1, P2X2, and P2X2-X3. NF546 (100 μM; 24 hours) is equi-efficacious in stimulating TSP-1 release and inhibiting the LPS-induced release of IL-12p70 in human monocyte-derived dendritic cells^[1].

1180.74

C₄₇H₄₄N₆Na₄O₁₇P₄

1006028-37-0

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.