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2-Methylthioadenosine diphosphate trisodium
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
2-Methylthioadenosine diphosphate trisodium图片
CAS NO:475193-31-8
包装:5mg (10 mM * 927 μL in Water)
市场价:5200元

产品名称
2-Methylthio-ADP trisodium
产品介绍
2-Methylthioadenosine diphosphate trisodium (2-Methylthio-ADP trisodium) 是一种有效的嘌呤能P2Y受体激动剂，对人 P2Y13、小鼠 P2Y13 和人 P2Y12 的EC50分别为 19、6.2 和 5 nM。2-Methylthioadenosine diphosphate trisodium 对人 P2Y1 和大鼠 P2Y6 的 pEC50分别为 8.29 和 5.75。2-Methylthioadenosine diphosphate trisodium 诱导血小板聚集和形态改变，并抑制前列腺素E1作用下血小板内环腺苷酸的积累。
生物活性

2-Methylthioadenosine diphosphate trisodium is a potentpurinergic P2Yreceptors agonist, withEC50s of 19, 6.2, and 5 nM for human P2Y13, mouse P2Y13 and human P2Y12, respectively. 2-Methylthioadenosine diphosphate trisodium has pEC50s of 8.29 and 5.75 for human P2Y1 and rat P2Y6, respectively. 2-Methylthioadenosine diphosphate trisodium induces platelet aggregation and shape change, and inhibits cyclic AMP accumulation in platelets exposed to prostaglandin E1[1][2][3].

体外研究
(In Vitro)

2-Methylthioadenosine diphosphate trisodium (2-Methylthio-ADP trisodium) is a powerful aggregating agent for human platelets. 2-Methylthioadenosine diphosphate trisodium is also a powerful inhibitor of the accumulation of cyclic AMP in intact platelets exposed to PGE1 and a phosphodiesterase inhibitor[1].

分子量

539.24

性状

Liquid

Formula

C11H14N5Na3O10P2S

CAS 号

475193-31-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Solution, -20°C, 2 years