Orexin B, rat, mouse (Rat orexin B) TFA is an endogenousorexin receptoragonist. Orexin B, rat, mouse TFA binds and activates two closely related orphan G protein-coupled receptors OX1-R and OX2-R. Orexin B, rat, mouse TFA stimulates food intake and energy expenditure and plays a significant role in sleep-wakefulness regulation^[1][2][3].

OX2 receptor is indeed a high-affinity receptor for human orexin B, with an IC₅₀of 36 nM in the binding assay and an EC₅₀of 60 nM in the [Ca²⁺]i transient assay. Human Orexin B has significantly lower affinity for the human OX1: the calculated IC₅₀in the competitive binding assay and the EC₅₀in the [Ca²⁺]i transient assay are 420 nM and 2500 nM for human orexin-B, respectively^[2].

Orexin-B modulates the activity of rod bipolar cells (RBCs) located in the outer retina of rat. Intravitreal injection of orexin-B increased the amplitude of the scotopic electroretinographic b-wave, a reflection of RBC activity, recorded in vivo^[4].

3050.42

Solid

C128H216F3N45O36S

RPGPPGLQGRLQRLLQANGNHAAGILTM-NH2

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

H₂O : 100 mg/mL(32.78 mM;Need ultrasonic)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。