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[Leu31,Pro34]-Neuropeptide Y(human,rat)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CAS NO:132699-73-1
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
[Leu31,Pro34]-Neuropeptide Y(human,rat) 是一种特定的神经肽 YY1受体激动剂。[Leu31,Pro34]-Neuropeptide Y(human,rat) 也激活 Y4，Y5。[Leu31,Pro34]-Neuropeptide Y(human,rat) 可以增加麻醉大鼠的血压，也增加饮食摄入量。
生物活性

[Leu31,Pro34]-Neuropeptide Y(human,rat) is a specificneuropeptide Y Y1receptoragonist. [Leu31,Pro34]-Neuropeptide Y(human,rat) slao activates Y4, Y5. [Leu31,Pro34]-Neuropeptide Y(human,rat) can increase blood pressure in anesthetized rats and increases food intake[1][2].

IC50& Target[1][2]

NPY Y1receptor

 

NPY Y4receptor

 

NPY Y5receptor

 

体外研究
(In Vitro)

[Leu31,Pro34]-Neuropeptide Y(human,rat) has Kivalues of 0.39 nM, 0.499 nM, 0.31 nM for Y1, Y4, Y5in HEK cell lines. [Leu31,Pro34]-Neuropeptide Y(human,rat) has a Kiof >1000 for Y2in HEK cell lines[2].

体内研究
(In Vivo)

[Leu31,Pro34]-Neuropeptide Y(human,rat) (30 pmol; microinjected into paraventricular nucleus) increases food intake in the rats (350±400 g)[3].

分子量

4240.73

Formula

C189H284N54O56S

CAS 号

132699-73-1

Sequence

Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Leu-Thr-Arg-Pro-Arg-Tyr-NH2

Sequence Shortening

YPSKPDNPGEDAPAEDMARYYSALRHYINLLTRPRY-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

 ContentsAssign value
Acidic amino acidAsp (D), Glu (E), and the C-terminal -COOH.-1
Basic amino acidArg (R), Lys (K), His (H), and the N-terminal -NH2+1
Neutral amino acidGly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)0

3.  Recommended solution:

Overall charge of peptideDetails
Negative (<0)1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0)1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.