RFRP-3 (Neuropeptide VF(124-131))(human) TFA, a humanGnIH peptidehomolog, is a potent inhibitor ofgonadotropin secretionby inhibiting Ca²⁺ mobilization. RFRP-3(human) is aNPFF1 receptoragonist, it inhibits forskolin-induced production of cAMP with an IC₅₀of 0.7 nM^[1].

RFRP-3 TFA efficiently inhibits forskolin-induced production of cAMP with an IC₅₀of 0.7 nM^[1].
Scatchard-plot analysis shows that¹²⁵I-labelled hRFRP-3 has a single class of high-affinity binding sites for the membrane fractions of CHO cells expressing rat OT7T022, the K_dvalue and the B_maxvalues are 0.19 nM and 1.3 pM, respectively.
RFRP-3 TFA specifically stimulate cells transfected with a new orphan 7TMR, OT7T022, it binds to OT7T022 as a specific ligand with high affinity (K_d= 0.19 nM)^[1].
RFRP-3 (10^-8 to 10^-14M) has no effect on LH and FSH levels alone, but when it combines with GnRH, LH and FSH secretion is significantly reduced by the combination^[1].

1083.16

C₄₇H₇₃F₃N₁₄O₁₂

VPNLPQRF-NH2

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