GalaninReceptor Ligand M35 TFA is a high-affinity ligand and antagonist ofgalaninreceptor(K_d=0.1 nM).GalaninReceptor Ligand M35 TFA exerts aK_ivalues of 0.11 and 2.0 nM for humangalaninreceptor type 1 and 2, respectively^[1][2].

Galanin Receptor Ligand M35 TFA has a dual effect on the galanin mediated inhibition of Forskolin stimulated cyclic AMP production in Rin m 5F cells. Co-applied with galanin (10 nM), Galanin Receptor Ligand M35 TFA at low concentrations (1 nM) is able to reverse the inhibitory effect of galanin. But when present at higher concentrations (15 and 30 nM), Galanin Receptor Ligand M35 TFA acts as a galanin receptor agonist, inhibiting the forskolin stimulated production of cAMP^[1].

Galanin Receptor Ligand M35 TFA (6 nM/10 μL; i.c.v.) improves the ability of the male Sprague-Dnwley rats to acquire the swim maze task^[3].

2347.62

C₁₀₉H₁₅₄N₂₇F₃O₂₈

Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-NH2

GWTLNSAGYLLGPPPGFSPFR-NH2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.