| CAS NO: | 683746-68-1 |
| 包装 | 价格(元) |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| 生物活性 | JNJ-5207787 is a nonpeptidic, selective and penetrate the blood-brain barrierneuropeptide Y Y2receptor (Y2)antagonist. JNJ-5207787 inhibits the binding of peptide YY (PYY) withpIC50s of 7.0 and 7.1 for human Y2receptor and rat Y2receptor, respectively. JNJ-5207787 is >100-fold selective versus human Y1, Y4, and Y5receptors[1]. | |||||||||
| IC50& Target[1] |
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| 体外研究 (In Vitro) | JNJ-5207787 (0.01, 0.1, 1, 10 μM) has antagonistic properties and inhibits the PYY-stimulated [35S]GTPγS binding to basal level with a p IC50corr of 7.20[1]. | |||||||||
| 体内研究 (In Vivo) | JNJ-5207787 (i.p.; 30 mg/kg) penetrates into the brain (Cmax=1351 ng/ml at 30 min) and occupies Y2receptor binding sites[1].
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| 分子量 | 510.67 | |||||||||
| 性状 | Solid | |||||||||
| Formula | C32H38N4O2 | |||||||||
| CAS 号 | 683746-68-1 | |||||||||
| 运输条件 | Room temperature in continental US; may vary elsewhere. | |||||||||
| 储存方式 |
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