(Leu31,Pro34)-Peptide YY(human)

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

179986-95-9

包装与价格：

产品介绍

(Leu31,Pro34)-Peptide YY (human) 是一种 Peptide YY (HY-P1514) 的衍生物，是一种有效的、选择性的Y₁激动剂，K_D为 1.0 nM。

生物活性

(Leu31,Pro34)-Peptide YY (human) is aPeptide YY(HY-P1514) derivative and is a potent and selectiveY₁agonist with aK_Dof 1.0 nM^[1].

IC₅₀& Target^[1]

NPY Y₁receptor

1.0 nM (Kd)

NPY Y₂receptor

670 nM (Kd)

体外研究
(In Vitro)

(Leu31,Pro34)-Peptide YY 在大鼠额顶叶皮质膜制剂 (Y₁富集组织) 和兔大隐静脉 (Y₁体外生物测定) 中表现出高亲和力 (nM)，但在 Y₂富集制剂 (大鼠海马) 中仅表现出低亲和力^[1]。

体内研究
(In Vivo)

(Leu31,Pro34)-Peptide YY (0.1-1 nmol/day; ICV; 14 days) 对大鼠有抗焦虑和抗抑郁作用^[2]。

Animal Model:	Male Sprague Dawley rats weighing 150-170 g, OBX/Sham model^[2]
Dosage:	0.1, 0.3 and 1 nmol/day
Administration:	ICV, for 14 days
Result:	Significantly decreased hyperlocomotion and immobility time in OBX animals. Reversed the deficit in social contacts in OBX animals. Reduced grooming behavior in sham animals.

分子量

4292.75

Formula

C₁₉₅H₂₉₆N₅₄O₅₆

CAS 号

179986-95-9

Sequence Shortening

YPIKPEAPGEDASPEELNRYYASLRHYLNLLTRPRY-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

H₂O

Peptide Solubility and Storage Guidelines:

1. Calculate the length of the peptide.

2. Calculate the overall charge of the entire peptide according to the following table:

	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3. Recommended solution:

Overall charge of peptide	Details
Negative (<0)	1. Try to dissolve the peptide in water first. 2. If water fails, add NH₄OH (<50 μL). 3. If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0)	1. Try to dissolve the peptide in water first. 2. If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3. If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1. Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2. For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.