M40 is a potent, non-selectivegalaninreceptorantagonist.

M40 (1 μM) displaces [mono[¹²⁵IJodo-Tyr²⁶]galanin from binding sites in the hippocampus, hypothalamus, and spinal cord. M40 has a lower affinity than galanin for all membranes. The IC₅₀values are 6 nM in the hippocampus, 15 nM in the hypothalamus, 12 nM in the spinal cord, and 3 nM in the insulinoma cells. M40 (1 μM) completely blocks¹²⁵I-labeled galanin-binding sites^[1].

1980.31

Solid

C₉₅H₁₄₆N₂₂O₂₄

143896-17-7

Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Pro-Pro-Ala-Leu-Ala-Leu-Ala-NH2

GWTLNSAGYLLGPPPALALA-NH2

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)