CAS NO: | 138579-66-5 |
包装 | 价格(元) |
500 μg | 电议 |
1mg | 电议 |
5mg | 电议 |
生物活性 | Galantide, a non-specificgalaninreceptorantagonist, is a peptide consisting of fragments ofgalaninand substance P. Galantide recognizes two classes ofgalaninbinding sites (KD<0.1 nM and ~6 nM) in the rat hypothalamus. Galantide dose dependently (IC50=1.0 nM) antagonizes the galanin-mediated inhibition of the glucose-inducedinsulinsecretion from mouse pancreatic islets. Galantide appears to bind to a single population of SP receptors (KD~40 nM)[1][2][3]. | ||||||
体外研究 (In Vitro) | Galantide do not activate the K+conductance but produces a concentration-dependent antagonism (IC50=4 nM) of the galanin-induced increase in K+conductance. Galantide acts like galanin and inhibits the voltage-dependent Ba2+ current (IBa). The inhibition of IBa also is concentration dependent (IC50=16 nM) and the maximum inhibition produced by galantide is approximately 40%[3]. | ||||||
体内研究 (In Vivo) | Intracerebroventricular injection of galanin (5 micrograms/rat) inhibited sexual behavior in experienced male rats--without producing any other locomotor or behavioral deficit-, injection of the galanin antagonist, galantide, by the same route (1 or 2 micrograms/rat) stimulated sexual behavior (improving arousal, motivation and performance indexes) and antagonized the effect of galanin[2]. Galantide ameliorates mild acute pancreatitis (AP). Galantide significantly reduces AP-induced hyperenzymemia by 41–49%[3]. Galantide has been found to improve social memory in 'socialrecognition' test when i.c.v. administered at doses varying from 6-6000 nM[4]. | ||||||
分子量 | 2199.53 | ||||||
性状 | Solid | ||||||
Formula | C104H151N25O26S | ||||||
CAS 号 | 138579-66-5 | ||||||
Sequence | Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 | ||||||
Sequence Shortening | GWTLNSAGYLLGPQQFFGLM-NH2 | ||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||
储存方式 | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |