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Galantide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:138579-66-5
包装与价格:
包装价格(元)
500 μg电议
1mg电议
5mg电议

产品介绍
Galantide 是一种特殊的甘丙肽受体 (galanin receptor) 拮抗剂,是一种由甘丙肽和 P 物质片段组成的肽段,在大鼠下丘脑可识别两类甘丙肽结合位点 (KD分别小于 0.1 nM 和 ~6 nM)。Galantide 剂量依赖性 (IC50=1.0 nM) 拮抗甘丙肽介导的葡萄糖诱导的小鼠胰岛胰岛素分泌抑制。Galantide 似乎与单一的 SP 受体群结合 (KD~40 nM)。
生物活性

Galantide, a non-specificgalaninreceptorantagonist, is a peptide consisting of fragments ofgalaninand substance P. Galantide recognizes two classes ofgalaninbinding sites (KD<0.1 nM and ~6 nM) in the rat hypothalamus. Galantide dose dependently (IC50=1.0 nM) antagonizes the galanin-mediated inhibition of the glucose-inducedinsulinsecretion from mouse pancreatic islets. Galantide appears to bind to a single population of SP receptors (KD~40 nM)[1][2][3].

体外研究
(In Vitro)

Galantide do not activate the K+conductance but produces a concentration-dependent antagonism (IC50=4 nM) of the galanin-induced increase in K+conductance. Galantide acts like galanin and inhibits the voltage-dependent Ba2+ current (IBa). The inhibition of IBa also is concentration dependent (IC50=16 nM) and the maximum inhibition produced by galantide is approximately 40%[3].

体内研究
(In Vivo)

Intracerebroventricular injection of galanin (5 micrograms/rat) inhibited sexual behavior in experienced male rats--without producing any other locomotor or behavioral deficit-, injection of the galanin antagonist, galantide, by the same route (1 or 2 micrograms/rat) stimulated sexual behavior (improving arousal, motivation and performance indexes) and antagonized the effect of galanin[2]. Galantide ameliorates mild acute pancreatitis (AP). Galantide significantly reduces AP-induced hyperenzymemia by 41–49%[3]. Galantide has been found to improve social memory in 'socialrecognition' test when i.c.v. administered at doses varying from 6-6000 nM[4].

分子量

2199.53

性状

Solid

Formula

C104H151N25O26S

CAS 号

138579-66-5

Sequence

Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2

Sequence Shortening

GWTLNSAGYLLGPQQFFGLM-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder-80°C2 years
-20°C1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)