RTI-118 is a novel small-moleculeneuropeptide S receptor (NPSR)antagonist. RTI-118 can relieve drug addiction including selectively decrease cocaine self-administration^[1].

RTI-118 (109 nM) has a reduction in antagonist potency at the NPS 107I variant^[2].

RTI-118 (5-30 mg/kg, intraperitoneal injection; pre-30 minutes) is well tolerated in rats with no significant outward signs of aversion, sedation or toxicity, it also produces a dose-related decrease in cocaine and food self-administration; however these effects are selective for cocaine at lower doses (10 and 20 mg/kg)^[1].

448.56

C₂₆H₃₂N₄O₃

847554-50-1

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