Fosnetupitant (Pronetupitant) a methylene phosphate prodrug of Netupitant. Fosnetupitant (Pronetupitant) exhibits a pK_iof 9.5 forhuman NK₁receptor^[1].

Fosnetupitant (Pronetupitant) displays micromolar affinity for the 5-HT6 (pK_i~ 5.2) receptor and type L Ca²⁺channels (pK_i~ 5.7) and does not bind all the other proteins investigated^[1].

Pronetupitant is rapidly and extensively converted to Netupitant after i.v. injection in rats^[1].

688.60

Solid

C₃₁H₃₅F₆N₄O₅P

1703748-89-3

Room temperature in continental US; may vary elsewhere.

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

DMSO : 100 mg/mL(145.22 mM;Need ultrasonic)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (protect from light, stored under nitrogen)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。