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Cinnabarinic acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cinnabarinic acid图片
CAS NO:606-59-7
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品名称
朱砂精酸
产品介绍
Cinnabarinic acid 是mGlu4特异性的别构激动剂,可以与 mGlu4 的谷氨酸结合袋残基相互作用,在其他 mGlu 受体亚型上没有活性。Cinnabarinic acid 是色氨酸 kynurenine 途径的内源性代谢物。Cinnabarinic acid 可以诱导细胞凋亡 (apoptosis)。
生物活性

Cinnabarinic acid is a specific orthosteric agonist ofmGlu4by interacting with residues of the glutamate binding pocket of mGlu4, has no activity at other mGlu receptors. Cinnabarinic acid is anendogenous metaboliteof the kynurenine pathway of tryptophan. Cinnabarinic acid induces cellapoptosis[1].

IC50& Target[1]

mGluR4

 

体外研究
(In Vitro)

Cinnabarinic acid (0-100 μM) does not activate mGlu1, mGlu2, mGlu5, mGlu6, mGlu7, and mGlu8 receptors as shown by measurements of [3H]InsP formation. In contrast, cinnabarinic acid acts as a partial agonist of mGlu4 receptors by increasing [3H]InsP formation by approximately 35% at 100 μM, which is 5-fold less efficacious than ACPT-I in activating mGlu4 receptors in HEK293 cells transiently transfected with rat mGlu1, -2, -4, -5, -6, -7, or -8 receptors[1].
Cinnabarinic acid (0-100 μM) reduces cAMP formation in a concentration-dependent manner with an excellent potency and efficacy. At 30 μM, cinnabarinic acid is effective at 30 μM, and substantially inhibits cAMP formation in cultured cerebellar granule cells[1].

分子量

300.22

Formula

C14H8N2O6

CAS 号

606-59-7

中文名称

朱砂精酸

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.