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AZD 2066
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AZD 2066图片
CAS NO:934282-55-0
包装:5mg
市场价:5850元

产品介绍
AZD 2066 是一种选择性的,具有口服活性和可透过血脑屏障的mGluR5的拮抗剂。AZD 2066 具有抗伤害作用。
生物活性

AZD 2066 is a selective, orally active and brain-penetrant antagonist ofmGluR5. AZD 2066 has antinociception effects[1].

IC50& Target

mGluR5

 

体外研究
(In Vitro)

AZD 2066 (1-10 μM) inhibits Ca2+response, with IC50s of 27.2±9.1, 3.56±0.52, 96.2±17.8, and 380±78.0 nM in mGlu5/HEK cells and striatal, hippocampal, and cortical cultures respectively[2].
AZD 2066 (1-10 μM) inhibits the oscillatory Ca2+response which induced by bath application of DHPG, and blocks either DHPG or Quis effects in mGlu5/HEK cells[2].
AZD 2066 (1-10 μM) has less effective in striatal neurons[2].

体内研究
(In Vivo)

AZD 2066 (0.3-30 mg/kg; p.o.) shows discriminative effects in rats[1].

Animal Model:Male Wistar rats (weighing 240-250 g)[1]
Dosage:0.03, 0.1, 0.3, 1, 3, 10, 30 mg/kg
Administration:P.o. (60 minutes after administration)
Result:Caused full and dose-dependent AZD9272-appropriate responding.
Clinical Trial
分子量

381.82

性状

Solid

Formula

C19H16ClN5O2

CAS 号

934282-55-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month