mGluR5 modulator1 is amGluR5positive allosteric modulator.mGluR5 modulator1 can be used for the research of the schizophrenia and cognitive impairments^[1].

mGluR5^[1]

mGluR5 modulator 1 (compound 2c; 0.1-0.00001 nM) potentiates the L-glutamate and DHPG responses to the same maximum response as the orthosteric agonists alone in the Ca²⁺mobilization and IP1 accumulation assays^[1].
mGluR5 modulator 1 (0.1-0.00001 nM) potentiates the L-glutamate and DHPG responses above the orthosteric agonist maximal response in the ERK1/2 phosphorylation assay^[1].
mGluR5 modulator 1 induces mGlu5 internalization in the absence of add orthosteric agonist or antagonist^[1].
mGluR5 modulator 1 potentiates the responses induced by both orthosteric agonists (L-glutamate or DHPG) in Ca²⁺mobilization (pK_B=5.4 and 5.3, respecyively), inositol monophosphate accumulation, and ERK1/2 phosphorylation signaling (pK_B=5.88 and 5.4, respecyively) assays in HEK293A-mGlu₅-low cells^[1].
mGluR5 modulator 1 enhances the effect of DHPG in cortical neurons with pEC₅₀values of 6.32 and 6.33 in Ca²⁺mobilization and inositol monophosphate (IP1) accumulation assays^[1].

363.81

C₁₈H₁₉ClFN₃O₂

1261171-52-1

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