CPPHA is potent and selective positive allosteric modulator (PAM) of themGluR5andmGluR1(metabotropic glutamate receptor). CPPHA can potentiate responses ofmGluR5andmGluR1to activation of these receptors. CPPHA is developed for the research of central nervous system disorders^[1][2].

CPPHA alone has no agonist activity^[1].
CPPHA causes concentration-dependent potentiation of the response of human mGluR5 CHO cells to agonists^[1].
CPPHA potentiates threshold response to glutamate in fluorometric Ca²⁺assays 7- to 8-fold with EC₅₀values in the 400 to 800 nM range^[1].
CPPHA (20 μM; 15 minutes) potentiates the response to a subthreshold concentration of DHPG (HY-12598A) on ERK and cyclic-AMP responsive element-binding protein (CREB) activity, as well as NMDA receptor subunit NR1 phosphorylation in cortical and hippocampal slices^[3].

406.82

Solid

C₂₂H₁₅ClN₂O₄

693288-97-0

Room temperature in continental US; may vary elsewhere.

DMSO : 100 mg/mL(245.81 mM;Need ultrasonic)

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请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
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• 1.

  请依序添加每种溶剂： 10% DMSO    90%corn oil

  Solubility: ≥ 2.5 mg/mL (6.15 mM); Clear solution

  此方案可获得 ≥ 2.5 mg/mL (6.15 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

  以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。