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L-Cysteinesulfinic acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
L-Cysteinesulfinic acid图片
CAS NO:1115-65-7
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议

产品名称
L-半胱氨酸亚磺酸
产品介绍
L-Cysteinesulfinic acid 是一种有效的代谢型谷氨酸受体 (mGluRs) 激动剂,作用于mGluR1,mGluR5,mGluR2,mGluR4,mGluR6 和 mGluR8,pEC50分别为 3.92,4.6,3.9,2.7,4.0,和 3.94。
生物活性

L-Cysteinesulfinic acid is a potent agonist at several ratmetabotropic glutamate receptors(mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 formGluR1,mGluR5,mGluR2,mGluR4,mGluR6, andmGluR8, respectively[1].

IC50& Target

mGluR1

3.92 (pEC50)

mGluR2

3.9 (pEC50)

mGluR4

2.7 (pEC50)

mGluR5

4.6 (pEC50)

mGluR6

4.0 (pEC50)

mGluR8

3.94 (pEC50)

Human Endogenous Metabolite

 

体外研究
(In Vitro)

L-Cysteinesulfinic acid is an endogenous agonist of a metabotropic receptor coupled to stimulation of phospholipase D (PLD) activity. L-CSA is an endogenous agonist of the PLD-coupled metabotropic excitatory amino acids (EAA) receptor. L-CSA selectively activates the PLD-coupled receptor. 1 mM L-CSA induces a significant increase in PLD activity in hippocampal slices, whereas 1 mM concentrations of L-glutamate, L-aspartate, and L-HCA are without effect. L-CSA elicits a dose-dependent increase in PLD activity in rat hippocampal slices in the presence of iGluR antagonists, with an approximate EC50of 500 uM. The PLD response induced by 1 mM L-CSA is not significantly decreased in the presence of 1 uM tetrodotoxin, suggesting that this response is not dependent upon L-CSA-induced increases in cell firing[1].

分子量

153.16

性状

Solid

Formula

C3H7NO4S

CAS 号

1115-65-7

中文名称

L-半胱氨酸亚磺酸

结构分类
  • Ketones, Aldehydes, Acids
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

H2O : 125 mg/mL(816.14 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM6.5291 mL32.6456 mL65.2912 mL
5 mM1.3058 mL6.5291 mL13.0582 mL
10 mM0.6529 mL3.2646 mL6.5291 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。