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O-Phospho-L-serine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
O-Phospho-L-serine图片
CAS NO:407-41-0
包装与价格:
包装价格(元)
100mg电议
200mg电议
500mg电议

产品名称
L-Serine O-phosphate
L-SOP
产品介绍
O-Phospho-L-serine 是 L-serine 合成过程中的直接前体物质,是第三组mGluR(mGluR4,mGluR6,mGluR7 和 mGluR8) 的激动剂,O-Phospho-L-serine 同时为mGluR1mGluR2的拮抗剂。
生物活性

O-Phospho-L-serine is the immediate precursor to L-serine in the serine synthesis pathway, and an agonist at thegroup IIImGluRreceptors(mGluR4,mGluR6,mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist formGluR1and a potent antagonist formGluR2[1].

IC50& Target

Human Endogenous Metabolite

 

mGluR1

 

mGluR2

 

mGluR4

 

mGluR6

 

mGluR7

 

mGluR8

 

体外研究
(In Vitro)

O-Phospho-L-serine (l-SOP) weakly binds to mGluR1, and antagonizes the effects of l-glutamate. l-SOP activates the group III receptors (mGluR4, mGluR6, mGluR7, and mGluR8), but mGluR7 has much lower affinity for l-SOP than the other group III receptors and also displays lower efficacy for both ligands[1]. O-Phospho-L-serine (l-SOP) generates enhanced intracellular calcium responses in mGluR4 transfected cells. l-SOP inhibits the l-glutamate mediated mGluR1 response, with a Kiof 1 mM; l-SOP displays a substantially more potent inhibition of mGluR2 activation, with a Kiof 1 μM, three orders-of-magnitude more potent than for mGluR1. l-SOP induces membrane potential changes in HEK/TRPC4 cells transfected with mGluR4 or mGluR6. l-SOP induces TRPC4β activation mediated by Gαi/oproteins[2]. O-Phospho-L-serine (L-SOP) inhibits Müller glia proliferation, without affecting light-induced photoreceptor cell death. L-SOP disrupts Müller glia proliferation subsequent to or in parallel with the activation of ascl1a and stat3 expression in the light-damaged retina. L-SOP inhibits cone cell regeneration in the light-damaged retina[3].

分子量

185.07

性状

Solid

Formula

C3H8NO6P

CAS 号

407-41-0

结构分类
  • Ketones, Aldehydes, Acids
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

H2O : 1 mg/mL(5.40 mM;Need ultrasonic)

DMSO : 1 mg/mL(5.40 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM5.4034 mL27.0168 mL54.0336 mL
5 mM1.0807 mL5.4034 mL10.8067 mL
10 mM---------
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。