CAS NO: | 407-41-0 |
包装 | 价格(元) |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | O-Phospho-L-serine is the immediate precursor to L-serine in the serine synthesis pathway, and an agonist at thegroup IIImGluRreceptors(mGluR4,mGluR6,mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist formGluR1and a potent antagonist formGluR2[1]. | ||||||||||||||||
IC50& Target |
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体外研究 (In Vitro) | O-Phospho-L-serine (l-SOP) weakly binds to mGluR1, and antagonizes the effects of l-glutamate. l-SOP activates the group III receptors (mGluR4, mGluR6, mGluR7, and mGluR8), but mGluR7 has much lower affinity for l-SOP than the other group III receptors and also displays lower efficacy for both ligands[1]. O-Phospho-L-serine (l-SOP) generates enhanced intracellular calcium responses in mGluR4 transfected cells. l-SOP inhibits the l-glutamate mediated mGluR1 response, with a Kiof 1 mM; l-SOP displays a substantially more potent inhibition of mGluR2 activation, with a Kiof 1 μM, three orders-of-magnitude more potent than for mGluR1. l-SOP induces membrane potential changes in HEK/TRPC4 cells transfected with mGluR4 or mGluR6. l-SOP induces TRPC4β activation mediated by Gαi/oproteins[2]. O-Phospho-L-serine (L-SOP) inhibits Müller glia proliferation, without affecting light-induced photoreceptor cell death. L-SOP disrupts Müller glia proliferation subsequent to or in parallel with the activation of ascl1a and stat3 expression in the light-damaged retina. L-SOP inhibits cone cell regeneration in the light-damaged retina[3]. | ||||||||||||||||
分子量 | 185.07 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C3H8NO6P | ||||||||||||||||
CAS 号 | 407-41-0 | ||||||||||||||||
结构分类 |
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运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: H2O : 1 mg/mL(5.40 mM;Need ultrasonic) DMSO : 1 mg/mL(5.40 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |