S-22153

立即咨询

S-22153

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

180304-07-8

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议

产品介绍

S-22153 是一种有效的褪黑素受体 (melatonin receptor) 拮抗剂，对 hMT₁和 hMT₂的EC₅₀值分别为 19 nM 和 4.6 nM。S-22153 对 hMT₁的K_i值为 8.6 nM (CHO 细胞) 和 16.3 nM (HEK 细胞)，hMT₂的K_i值为 6.0 nM (CHO 细胞) 和 8.2 nM (HEK 细胞)。S-22153 是 MT₁和 MT₂褪黑素受体亚型的特异性配体。

生物活性

S-22153 is a potentmelatonin receptorantagonist withEC₅₀values of 19 nM, 4.6 nM forhMT₁andhMT₂melatonin receptor, respectively. S-22153 hasK_ivalues of 8.6 nM (CHO cells) and 16.3 nM (HEK cells) for hMT₁, and 6.0 nM (CHO cells) and 8.2 nM (HEK cells) for hMT₂. S-22153 is a specific ligand of MT₁and MT₂melatonin receptors subtypes^[1]^[2].

IC₅₀& Target^[2]

MT1

19 nM (EC₅₀)

MT2

4.6 nM (EC₅₀)

体内研究
(In Vivo)

S-22153 sets the temperature and activity periods to approximately 24 hr and increase the circadian amplitude of both rhythms in mice, which exposed to continuous light^[1].

Animal Model:	7 weeks old Male B6D2F1 mice, which exposed to continuous light for 10-18 days^[1]
Dosage:	20 mg/kg
Administration:	Daily intraperitoneal (i.p.) for 19 days
Result:	Set the temperature and activity periods to approximately 24 hr and increased the circadian amplitude of both rhythms in mice, which exposed to continuous light.

分子量

247.36

Formula

C₁₄H₁₇NOS

CAS 号

180304-07-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.