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Agomelatine-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Agomelatine-d4图片
CAS NO:1079389-44-8
包装与价格:
包装价格(元)
1mg电议
10mg电议

产品名称
S-20098-d4
产品介绍
Agomelatine-d4 (S-20098-d4) 是 Agomelatine 的氘代物。Agomelatine (S-20098) 是一种MT1MT2受体的特异性激动剂,对 CHO-hMT1,HEK-hMT1,CHO-hMT2,HEK-hMT2 的Ki分别为 0.1,0.06,0.12 和 0.27 nM。Agomelatine 还是一种选择性的5-HT2C受体拮抗剂,在天然 (猪) 和克隆的人 5-HT2C 受体中pKi分别为 6.4 和 6.2。
生物活性

Agomelatine-d4 (S-20098-d4) is the deuterium labeled Agomelatine. Agomelatine (S-20098) is a specific agonist ofMT1andMT2receptors withKis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively[1]. Agomelatine is a selective5-HT2C receptorantagonist withpKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively[2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

分子量

247.33

Formula

C15H13D4NO2

CAS 号

1079389-44-8

中文名称

阿戈美拉汀 d4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.