Tasimelteon-d5 (BMS-214778-d5) is the deuterium labeled Tasimelteon. Tasimelteon (BMS-214778) is an orally active and selectivedualmelatonin receptor agonist(DMRA). Tasimelteon has 2.1-4.4 times greater affinity for theMT2receptor than for theMT1receptor. Tasimelteon is a circadian regulator and has the potential for Non-24-Hour Sleep-Wake Disorder (Non-24)^[1][2].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

250.35

C₁₅H₁₄D₅NO₂

1962124-51-1

他司美琼 d5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.