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HS014
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:207678-81-7
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
HS014 是一种高效、选择性的黑素皮质素-4(MC4)受体拮抗剂,对人 MC4、MC1、MC3 和 MC5 受体的Ki值分别为 3.16、108、54.4 和 694 nM。HS014 调节吗啡对小鼠行为的影响。HS014 增加自由喂养大鼠的食物摄取量。
生物活性

HS014 is a potent and selectivemelanocortin-4 (MC4) receptorantagonist, withKis of 3.16, 108, 54.4 and 694 nM for human MC4, MC1, MC3 and MC5 receptors, respectively. HS014 modulates the behavioral effects of morphine in mice. HS014 increases food intake in free-feeding rats[1][2][3].

体内研究
(In Vivo)

The dose-effect curve of morphine for locomotor activity was shifted downwards in C57Bl/6 mice pretreated with HS014 and in A(y) mice. The dose-effect curve of morphine for antinociception is shifted two- and threefold to the left in C57Bl/6 mice pretreated with HS014 and in A(y) mice, respectively[2].
Pretreatment with HS014 blocks the effect of IL-1beta on food intake and respiratory exchange ratio (RER) at later time points (beyond 8 h post injection), as well as the hypoactivity and increases metabolic rate[4].

分子量

1563.76

Formula

C71H94N20O17S2

CAS 号

207678-81-7

Sequence

Ac-Cys-Glu-His-{D-2Nal}-Arg-Trp-Gly-Cys-Pro-Pro-Lys-Asp-NH2 (Disulfide bridge:Cys1-Cys8)

Sequence Shortening

Ac-CEH-{D-2Nal}-RWGCPPKD-NH2 (Disulfide bridge:Cys1-Cys8)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.