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Amino-PEG5-C2-acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Amino-PEG5-C2-acid图片
包装与价格:
包装价格(元)
100mg电议
250mg电议

产品介绍
Amino-PEG5-C2-acid 是一种 PROTAC 连接桥,属于 PEG 类。Amino-PEG5-C2-acid 可用于合成一系列 PROTAC 分子。Amino-PEG5-C2-acid 是一种不可降解 (non-cleavable) 的 ADC 连接桥,用于抗体药物结合物 (ADCs) 的合成。

Non-cleavable

 

PEGs

 

产品描述

Amino-PEG5-C2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Amino-PEG5-C2-acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[1]. Gregory L. Verdine, et al. Stabilized polypeptide insulin receptor modulators. WO2014201370A1.