CAS NO: | 1706524-94-8 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | ML-00253764 hydrochloride is a brain penetrant nonpeptidicmelanocortin receptor4 (MC4R)antagonist with aKiandIC50of 0.16 μM and 0.103 μM, respectively[1]. | ||||||||
IC50& Target | Ki: 0.16 μMIC50: 0.103 μM (melanocortin receptor 4)[1] | ||||||||
体外研究 (In Vitro) | ML-00253764 displaces NDP-α-MSH binding with a mean IC50of 0.32 μM, 0.81 μM and 2.12 μM for hMC4-R, hMC3-R and hMC5-R, respectively[1].ML-00253764 (100 μM) decreases cAMP production induced by [NLE4,D-Phe7]-α-melanocyte stimulating hormone ([NDP]-α-MSH) by 20% in MC4R-expressing HEK293 cell membranes, but has no effect on cAMP levels in MC3R- or MC5R-expressing membranes[1]. | ||||||||
体内研究 (In Vivo) | ML-00253764 (subcutaneous injection; 3, 10, or 30 mg/kg; once daily) shows protection against tumor-induced body weight loss upon chronic, peripheral dosing in CT-26 tumor bearing BALB/c mice[1].ML-00253764 dissolves in polyethylene glycol 200/saline (1:10) in a volume of 10 mL/kg (For reference only)[1].
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分子量 | 413.71 | ||||||||
Formula | C18H19BrClFN2O | ||||||||
CAS 号 | 1706524-94-8 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |