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Tiotropium Bromide hydrate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tiotropium Bromide hydrate图片
CAS NO:411207-31-3
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
BA-679 BR (hydrate)
产品介绍
Tiotropium Bromide hydrate是长效的毒蕈碱受体拮抗剂。
生物活性

Tiotropium Bromide hydrate is an anticholinergic and bronchodilator and a muscarinic receptor antagonist. Target:mAChRTiotropium bromide (Ba 679 BR) is a novel potent and long-lasting muscarinic antagonist that has been developed for the treatment of chronic obstructive airways disease (COPD). Binding studies with [3H]tiotropium bromide in human lung have confirmed that this is a potent muscarinic antagonist with equal affinity for M1-, M2- and M3-receptors and is approximately 10-fold more potent than ipratropium bromide. In vitro tiotropium bromide has a potent inhibitory effect against cholinergic nerve-induced contraction of guinea-pig and human airways, that has a slower onset than atropine or ipratropium bromide. tiotropium bromide dissociates slowly from M3-receptors (on airway smooth muscle) but rapidly from M2 autoreceptors (on cholinergic nerve terminals) [1]. Tiotropium bromide is a quaternary ammonium derivative that binds to muscarinic receptors. However, although tiotropium binds with high affinity to muscarinic receptors of M1-, M2- and M3-subtypes, it dissociates very slowly from M1- and M3-receptors but more rapidly from M2-receptors, thereby giving it a unique kinetic selectivity [2].

Clinical Trial
分子量

490.43

Formula

C19H24BrNO5S2

CAS 号

411207-31-3

中文名称

噻托溴铵一水合物

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.