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Atropine hydrobromide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Atropine hydrobromide图片
CAS NO:6415-90-3
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
Tropine tropate hydrobromide
DL-Hyoscyamine hydrobromide
产品介绍
Atropine (Tropine tropate) hydrobromide 是一种竞争性的毒碱乙酰胆碱受体 (mAChR) 拮抗剂,拮抗 Human mAChR M4和 Chicken mAChR M4IC50值分别为 0.39 nM 和 0.71 nM。Atropine hydrobromide 抑制 ACh 诱导的人肺静脉松弛。Atropine hydrobromide 可用于抗近视和心动过缓研究。
生物活性

Atropine (Tropine tropate) hydrobromide is a competitivemuscarinic acetylcholine receptor(mAChR)antagonist withIC50values of 0.39 and 0.71 nM for HumanmAChRM4and ChickenmAChRM4, respectively. Atropine hydrobromide inhibits ACh-induced relaxations in human pulmonary veins. Atropine hydrobromide can be used for research of anti-myopia and bradycardia[1][2][3][4].

IC50& Target

IC50: 0.39 nM (Human mAChR M4) and 0.71 nM (Chicken mAChR M4)[3]

体外研究
(In Vitro)

Atropine (Tropine tropate; 1 μM; pulmonary veins and arteries) hydrobromide inhibits ACh-induced relaxations in human pulmonary veins[4].

体内研究
(In Vivo)

Atropine (Tropine tropate; 10 mg/kg; i.p.; once, for 40 minutes;Peromyscussp.) hydrobromide inhibits the cardiac arrhythmia which normally occurs throughout torpor[2].

Animal Model:White-footed mice (Peromyscussp.)[2]
Dosage:10 mg/kg
Administration:Intraperitoneal injection; once, for 40 minutes
Result:Increased heart rate was a decrease in cardiac arrhythmia.
Clinical Trial
分子量

370.28

Formula

C17H24BrNO3

CAS 号

6415-90-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.