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Fustin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Fustin图片
CAS NO:20725-03-5
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
(±)-Fustin
3,7,3',4'-Tetrahydroxyflavanone
产品介绍
Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) 是一种有效的淀粉样 β () 抑制剂。Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) 可增加 Aβ (1-42) 诱导的乙酰胆碱 (ACh) 水平、胆碱乙酰转移酶 (ChAT) 活性和 ChAT 基因的表达。Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) 降低 Aβ (1-42) 诱导的乙酰胆碱酯酶 (AChE) 活性和 AChE 基因表达。Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) 增加毒蕈碱 M1 受体基因表达和毒蕈碱 M1 受体结合活性。Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) 可用于阿尔茨海默氏病研究。
生物活性

Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) is a potentamyloid β (Aβ)inhibitor. Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) increases the expression of acetylcholine (ACh) levels, choline acetyltransferase (ChAT) activity, and ChAT gene induced by Aβ (1-42). Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) decreases in acetylcholinesterase(AChE) activity andAChEgene expression induced by Aβ (1-42). Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) increases muscarinic M1 receptor gene expression and muscarinic M1 receptor binding activity. Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) can be used for Alzheimer's disease research[1].

体内研究
(In Vivo)

Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) (50-100 mg/kg; p.o.; daily, for 11days; Aβ-treated C57BL/6 mice) attenuates Aβ (1-42)-induced impairments in conditioned fear learning and passive avoidance behavior[1].
Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) (50-100 mg/kg; p.o.; daily, for 11days; Aβ-treated C57BL/6 mice) alters Aβ (1-42)-induced changes in ACh level and AChE and ChAT activity and gene expression[1].
Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) (50-100 mg/kg; p.o.; daily, for 11days; Aβ-treated C57BL/6 mice) increases Aβ (1-42)-induced reduction in M1 receptor mRNA and protein expression in Aβ-treated C57BL/6 mice. Fustin increases p-ERK and p-CREB expression in Aβ-treated C57BL/6 mice[1].

Animal Model:Aβ-treated C57BL/6 mice[1]
Dosage:50 and 100 mg/kg
Administration:Oral administration;daily, for 11days
Result:Decreased freezing response in Aβ-treated C57BL/6 mice.
Animal Model:Aβ-treated C57BL/6 mice[1]
Dosage:50 and 100 mg/kg
Administration:Oral administration;daily, for 11days
Result:Increased the expression of Ach, ChAT gene and ChAT activity. Decreased the expression of AChE gene and AChE activity.
Animal Model:Aβ-treated C57BL/6 mice[1]
Dosage:50 and 100 mg/kg
Administration:Oral administration;daily, for 11days
Result:Increased gene expression of M2- , M3- ,M4-, M5-, α4β, α7-receptor, p-ERK and p-CREB.
分子量

288.25

Formula

C15H12O6

CAS 号

20725-03-5

结构分类
  • Flavonoids
  • Flavanonols
来源
  • Plants
  • Anacardiaceae
  • Rhus glabraL.
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.