MK-6884 is aM4 muscarinic receptorpositive allosteric modulator (PAM) with aK_ivalue of 0.19 nM. MK-6884 can be used for the research of the neurodegenerative diseases. MK-6884 can be conveniently radiolabeled with carbon-11 and as a positron emission tomography (PET) imaging agent^[1].

MK-6884 (compound 13; 0-22 μM) is a PAM of ACh function in a cell-based Ca²⁺mobilization assay, with an EC₅₀of 27 nM^[1].

[¹¹C]MK-6884 (compound 13) shows non-displaceable binding potential (BP_ND) of 0.83 in rhesus monkeys^[1].
[¹¹C]MK-6884 (approximately 185 MBq,<2 μg; single intravenous) distributes on the known presence of m4 receptors in rhesus monkeys brain^[1].
[¹¹C]MK-688 can penetrate the blood-brain barrier in monkeys^[1].

411.50

Solid

C₂₅H₂₅N₅O

2102194-04-5

Room temperature in continental US; may vary elsewhere.

THF : 3.33 mg/mL(8.09 mM;Need ultrasonic)

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