Pomalidomide-PEG6-butyl iodide

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CAS NO:

1835705-74-2

包装与价格：

产品介绍

Pomalidomide-PEG6-butyl iodide 是一种合成的 E3 ligase ligand-linker conjugate，包含基于 Pomalidomide 的 cereblon 配体和 6 个单元 PEG 的 linker。

Cas No.	1835705-74-2
别名	泊马度胺-PEG6-丁基碘
分子式	C31H44IN3O11
分子量	761.6
溶解度	DMSO : 100 mg/mL (131.30 mM; Need ultrasonic)
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Pomalidomide-PEG6-butyl iodide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 6-unit PEG linker used in PROTAC technology[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. [1]. Lai AC, et al. Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL. Angew Chem Int Ed Engl. 2016 Jan 11;55(2):807-10.