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L-Acetylcarnitine(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
L-Acetylcarnitine(hydrochloride)图片
CAS NO:5080-50-2
包装与价格:
包装价格(元)
1g电议
5g电议
10g电议
25g电议

产品介绍
Acetyl-L-carnitine (O-Acetyl-L-carnitine) hydrochloride 是体内发现的氨基酸 L-肉碱的血脑可渗透乙酰酯。
Cas No.5080-50-2
别名乙酰左旋肉碱,Acetyl-L-Carnitine,ALCAR
化学名(R)-3-acetoxy-4-(trimethylammonio)butanoate hydrochloride
Canonical SMILES[O-]C(C[C@H](C[N+](C)(C)C)OC(C)=O)=O.Cl
分子式C9H17NO4o HCl
分子量239.7
溶解度≥ 11mg/mL in DMSO with gentle warming
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

L-Acetylcarnitine, also named as ALCAR, an acetylated form of L-carnitine, fosters the uptake of acetyl coenzyme A (CoA) into mitochondria during fatty acid oxidation, raises the production of acetylcholine, and triggers the synthesis of membrane phospholipid and protein. ALCAR has been explored for use as an acetylcholine mimic as well as in targeting cardiovascular pathologies. Acetyl-CoA is the primary substrate for the tricarboxylic acid cycle in mitochondria and modulates the reserves of free CoA which is essential to the function of the tricarboxylic acid cycle.

In vitro: The expression of tumor antigen CA-125 in ovarian cancer cells was not affected by ALCAR. Comparing to the control, the growth of SKOV-3 cells was remarkably decreased when incubated with ALCAR. The proliferation of SKOV-3 cells was decreased slightly but significantly when cells were incubated at higher ALCAR concentrations. In addition, ALCAR had no effect on the expression of the nerve growth factor receptors on SKOV-3 or OVCAR-3 ovarian cancer cells [1].

In vivo: Male Flinders Sensitive Line (FSL) rats and male CD1 mice, exposed to model genetic and environmentally induced depression, respectively, were injected intraperitoneally with ALCAR 100 mg/kg for 21 days. ALCAR, as a long-lasting and rapid antidepressant, functioned via the epigenetic regulation of type 2 metabotropic glutamate (mGlu2) receptors in FSL rats and in mice. Additionally, ALCAR raised the transcription of Grm2 gene encoding for the mGlu2 receptor via increasing the levels of acetylated H3K27 bound to the Grm2 promoter and gaining the acetylation of NF-KB-p65 subunit. [2].

References:
[1].  Engle, D., Belisle, J., Gubbels, J., Petrie, S., Hutson, P., Kushner, D., & Patankar, M. Effect of acetyl-l-carnitine on ovarian cancer cells' proliferation, nerve growth factor receptor (Trk-A and p75) expression, and the cytotoxic potential of paclitaxel and carboplatin. Gynecologic Oncology. 2009; 112(3): 631-636.
[2].  Nasca, C., Xenos, D., Barone, Y., Caruso, A., Scaccianoce, S., & Matrisciano, F. et al. L-acetylcarnitine causes rapid antidepressant effects through the epigenetic induction of mGlu2 receptors. Proceedings of The National Academy of Sciences. 2013; 110(12): 4804-4809.