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TC LPA5 4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TC LPA5 4图片
CAS NO:1393814-38-4
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
200mg电议

产品介绍
TC LPA5 4 是一种特异性非脂质LPA5(GPR92)拮抗剂。TC LPA5 4 抑制 LPA 诱导的离体人血小板 (LPA5-RH7777细胞系) 聚集,IC50为 800 nM。TC LPA5 4 对 LPA5的选择性超过 80 个其他筛选药物靶点。TC LPA5 4 抑制甲状腺癌细胞的增殖和迁移。
生物活性

TC LPA5 4 is aLPA5(GPR92)-specific non-lipid antagonist. TC LPA5 4 inhibits LPA-induced aggregation of isolated human platelet (LPA5-RH7777 cell line) with an IC50of 800 nM. TC LPA5 4 displays selectivity for LPA5over 80 other screened drug targets[1]. TC LPA5 4 inhibits cell proliferation and migration of thyroidcancercells[2].

体外研究
(In Vitro)

TC LPA5 4 inhibits the proliferation on thyroid cancer cells CGTH-W3, TPC-1, B-CAPAP, and BHT101 significantly with IC50at 103.0 μM, 84.9 μM, 55.9μM, and 57.17 μM. TC LPA5 4 (5 μM; 24 hours) significantly inhibits LPA-stimulated migration of CGTH-W3 and TPC-1 cells, with an inhibitory rate of ~ 30%. B-CPAP and BHT101 cells expressed higher LPAR5 mRNA. TC LPA5 4 inhibits these two cell lines’ proliferations with IC50at 55.9μM and 57.17 μM. CGTH-W3 and TPC-1 cells expressed lower LPAR5 mRNA. TC LPA5 4 displays differential antitumor activity with IC50at 103.0 μM and 84.9 μM[2].

体内研究
(In Vivo)

TC LPA5 4 (10 mg/kg; intraperitoneal injection; 5 days/week for 2 weeks) could delay CGTH-W3 xenograft growth in nude mice[2].

Animal Model:BALB/C nu/nu mice, aged 4 5 weeks (CGTH-W3 xenografts)[2]
Dosage:10 mg/kg
Administration:Intraperitoneal injection; 5 days/week for 2 weeks
Result:Significantly inhibits CGTH-W3 xenograft growth with inhibitory rates of 46.7%.
分子量

410.89

性状

Solid

Formula

C23H23ClN2O3

CAS 号

1393814-38-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO : 62.5 mg/mL(152.11 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.4337 mL12.1687 mL24.3374 mL
5 mM0.4867 mL2.4337 mL4.8675 mL
10 mM0.2434 mL1.2169 mL2.4337 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (protect from light)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。